API reference
Flutamide
- CAS number
- 13311-84-7
- Molecular formula
- C11H11F3N2O3
- Molecular weight
- 276.21 g/mol
About this molecule
Flutamide is a toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- InChIKey
- MKXKFYHWDHIYRV-UHFFFAOYSA-N
- SMILES
- CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F
- Other CAS numbers recorded
- 37209-54-4
- PubChem CID
- 3397
Also known as
flutamide · Eulexin · Niftolide · NFBA · niftolid · Drogenil · Flutamida · Flutamidum
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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