API reference
Fosinopril sodium
- CAS number
- 88889-14-9
- Molecular formula
- C30H45NNaO7P
- Molecular weight
- 585.6 g/mol
About this molecule
Fosinopril Sodium is the sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium. (NCI05)
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- sodium (2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate
- InChIKey
- TVTJZMHAIQQZTL-HREVRLCXSA-M
- SMILES
- CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2C[C@@H](C[C@H]2C(=O)[O-])C3CCCCC3.[Na+]
- Other CAS numbers recorded
- 1217528-56-7 · 1608148-89-5
- PubChem CID
- 23681451
Also known as
FOSINOPRIL SODIUM · Staril · Fosinopril sodium salt · Eliten · Fositens · Newace · fosinopirl sodium · 620-449-1
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