API reference
FOSNETUPITANT CHLORIDE HCl
- CAS number
- 1643757-72-5
- Molecular formula
- C31H37Cl2F6N4O5P
- Molecular weight
- 761.5 g/mol
About this molecule
Fosnetupitant Chloride Hydrochloride is the chloride hydrochloride salt form of fosnetupitant, a prodrug of netupitant, a selective neurokinin 1 receptor (NK1R; TACR1) antagonist, with potential antiemetic activity. Upon intravenous administration, fosnetupitant is converted by phosphatases to its active form netupitant. Netupitant competitively binds to and blocks the activity of NK1Rs in the central nervous system (CNS), by inhibiting binding of the endogenous tachykinin-derived neuropeptide substance P (SP) to NK1R. This prevents delayed emesis, which is associated with SP secretion. This may prevent chemotherapy-induced nausea and vomiting (CINV).
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [4-[5-[[2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl]-methylamino]-4-(2-methylphenyl)-2-pyridinyl]-1-methylpiperazin-1-ium-1-yl]methyl dihydrogen phosphate;chloride;hydrochloride
- InChIKey
- LBTQUZNIWCWBNN-UHFFFAOYSA-N
- SMILES
- CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CC[N+](CC4)(C)COP(=O)(O)O.Cl.[Cl-]
- PubChem CID
- 86764535
Also known as
Fosnetupitant chloride · Fosnetupitant chloride hydrochloride · 08-PNET · Fosnetupitant dihydrochloride · FOSNETUPITANT CHLORIDE (USAN RESCINDED) · Fosnetupitant (chloride monohydrochloride ) · Fosnetupitant chloride monohydrochloride · Arokaris (TN)
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