API reference
Fostamatinib disodium hexahydrate
- CAS number
- 914295-16-2
- Molecular formula
- C23H36FN6Na2O15P
- Molecular weight
- 732.5 g/mol
About this molecule
Fostamatinib Disodium is an orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- disodium;[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate;hexahydrate
- InChIKey
- ZQGJCHHKJNSPMS-UHFFFAOYSA-L
- SMILES
- CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.O.O.O.O.O.O.[Na+].[Na+]
- Other CAS numbers recorded
- 1025687-58-4
- PubChem CID
- 24828759
Also known as
Fostamatinib disodium hexahydrate · Fostamatinib disodium · R788 SODIUM · R-788 Sodium · R788 SODIUM HYDRATE · R-788 SODIUM HYDRATE · FOSTAMATINIB SODIUM HYDRATE · Fostamatinib disodium salt hexahydrate
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
Tell us the grade, the quantity and the market.
Send the molecule or ingredient, the specification and the destination. We reply from Tehran with the questions, the documents and the next step.