API reference
Gatifloxacin
- CAS number
- 112811-59-3
- Molecular formula
- C19H22FN3O4
- Molecular weight
- 375.4 g/mol
About this molecule
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
- InChIKey
- XUBOMFCQGDBHNK-UHFFFAOYSA-N
- SMILES
- CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
- Other CAS numbers recorded
- 160738-57-8
- PubChem CID
- 5379
Also known as
Gatifloxacin · Tequin · Gatiflo · Zymar · Zymaxid · Zymer · gatifloxacin anhydrous · Gatifloxacine
Related entries in the range
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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