API reference
GEMCITABINE HCl
- CAS number
- 122111-03-9
- Molecular formula
- C9H12ClF2N3O4
- Molecular weight
- 299.66 g/mol
About this molecule
Gemcitabine Hydrochloride is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride
- InChIKey
- OKKDEIYWILRZIA-OSZBKLCCSA-N
- SMILES
- C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl
- PubChem CID
- 60749
Also known as
GEMCITABINE HYDROCHLORIDE · Gemcitabine HCl · Gemcitabine HCI · 2'-Deoxy-2',2'-difluorocytidine monohydrochloride · INFUGEM · 2'-deoxy-2',2'-difluorocytidine hydrochloride · Gemcitabine (as hydrochloride) · Cytidine, 2'-deoxy-2',2'-difluoro-, monohydrochloride
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