API reference
Gemfibrozil
- CAS number
- 25812-30-0
- Molecular formula
- C15H22O3
- Molecular weight
- 250.33 g/mol
About this molecule
Gemfibrozil is a fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
- InChIKey
- HEMJJKBWTPKOJG-UHFFFAOYSA-N
- SMILES
- CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
- Other CAS numbers recorded
- 114413-98-8
- PubChem CID
- 3463
Also known as
gemfibrozil · 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid · Lopid · Lipur · Jezil · Gemfibrozilo · Gemfibrozilum · Gemlipid
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
Tell us the grade, the quantity and the market.
Send the molecule or ingredient, the specification and the destination. We reply from Tehran with the questions, the documents and the next step.