API reference
Halobetasol propionate
- CAS number
- 66852-54-8
- Molecular formula
- C25H31ClF2O5
- Molecular weight
- 485 g/mol
About this molecule
Halobetasol Propionate is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
- InChIKey
- BDSYKGHYMJNPAB-LICBFIPMSA-N
- SMILES
- CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)CCl
- PubChem CID
- 6918178
Also known as
HALOBETASOL PROPIONATE · Ulobetasol propionate · Ultravate · Jemdel · CGP-14,458 · BRYHALI · DUOBRII COMPONENT HALOBETASOL PROPIONATE · LEXETTE
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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