API reference
IRINOTECAN HCl TRIHYDRATE
- CAS number
- 136572-09-3
- Molecular formula
- C33H45ClN4O9
- Molecular weight
- 677.2 g/mol
About this molecule
Irinotecan hydrochloride hydrate is a hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. It has a role as an antineoplastic agent, a prodrug, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an apoptosis inducer. It contains an irinotecan hydrochloride (anhydrous).
Source: ChEBI, via PubChem.
Identifiers
- IUPAC name
- [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;trihydrate;hydrochloride
- InChIKey
- KLEAIHJJLUAXIQ-JDRGBKBRSA-N
- SMILES
- CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl
- PubChem CID
- 60837
Also known as
Camptosar · Irinotecan hydrochloride hydrate · IRINOTECAN HYDROCHLORIDE Trihydrate · Irinotecan Hcl Trihydrate · CPT-11 Trihydrate · Irinotecan (hydrochloride trihydrate) · Irinotecan HCI Trihydrate · Camptosar (TN)
Related entries in the range
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