API reference
Ixazomib citrate
- CAS number
- 1239908-20-3
- Molecular formula
- C20H23BCl2N2O9
- Molecular weight
- 517.1 g/mol
About this molecule
Ixazomib Citrate is the citrate salt form of ixazomib, an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-[4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolan-4-yl]acetic acid
- InChIKey
- MBOMYENWWXQSNW-AWEZNQCLSA-N
- SMILES
- B1(OC(=O)C(O1)(CC(=O)O)CC(=O)O)[C@H](CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl
- PubChem CID
- 56844015
Also known as
Ixazomib citrate · NINLARO · Ixazomib citrate (Ester) · C20H23BCl2N2O9 · Lxazomib Citrate · Ninlaro (TN) · Ixazomib citrate (JAN/USAN) · Ixazomib Impurity N; Ixazomib Citrate
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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