API reference
Kanamycin sulfate
- CAS number
- 25389-94-0
- Molecular formula
- C18H38N4O15S
- Molecular weight
- 582.6 g/mol
About this molecule
Kanamycin Sulfate is the sulfate salt of kanamycin, a naturally occurring aminoglycoside antibiotic with antimicrobial property. Derived from Streptomyces kanamyceticus, kanamycin is an antibiotic complex consisting of three components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B and C, the minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
- InChIKey
- OOYGSFOGFJDDHP-KMCOLRRFSA-N
- SMILES
- C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O
- Other CAS numbers recorded
- 3847-27-6 · 133-92-6
- PubChem CID
- 441374
Also known as
Kanamycin A sulfate · Kanamycin A sulphate · Kanaplex · KANAMYCIN SULFATE (USP-RS) · KANAMYCIN SULFATE (USP MONOGRAPH) · KANAMYCIN MONOSULFATE (EP MONOGRAPH) · 223-347-1 · 613-414-7
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