API reference
Lacosamide
- CAS number
- 175481-36-4
- Molecular formula
- C13H18N2O3
- Molecular weight
- 250.29 g/mol
About this molecule
Lacosamide is a functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (2R)-2-acetamido-N-benzyl-3-methoxypropanamide
- InChIKey
- VPPJLAIAVCUEMN-GFCCVEGCSA-N
- SMILES
- CC(=O)N[C@H](COC)C(=O)NCC1=CC=CC=C1
- PubChem CID
- 219078
Also known as
Lacosamide · Erlosamide · Vimpat · Harkoseride · SPM 927 · SPM-927 · (r)-lacosamide 1 · MOTPOLY
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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