API reference
Lapatinib ditosylate
- CAS number
- 388082-78-8
- Molecular formula
- C43H44ClFN4O11S3
- Molecular weight
- 943.5 g/mol
About this molecule
Lapatinib Ditosylate is the ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;bis(4-methylbenzenesulfonic acid);hydrate
- InChIKey
- XNRVGTHNYCNCFF-UHFFFAOYSA-N
- SMILES
- CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.O
- PubChem CID
- 11557040
Also known as
Tyverb · lapatinib tosilate · Tycerb · Lapatinib tosilate hydrate · Lapatinib ditoluenesulfonate monohydrate · Lapatinib Ditosylate · LAPATINIB DITOSYLATE MONOHYDRATE · Lapatinib ditosylate hydrate
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