API reference
Levocetirizine dihydrochloride
- CAS number
- 130018-87-0
- Molecular formula
- C21H27Cl3N2O3
- Molecular weight
- 461.8 g/mol
About this molecule
Levocetirizine Dihydrochloride is the dihydrochloride salt form of the active levorotatory enantiomer of cetirizine, levocetirizine; a third generation, non-sedating, selective histamine H1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Levocetirizine competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. This prevents the negative symptoms associated with histamine release and an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the expression of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine H1 receptor antagonist, levocetirizine has fewer side effects than most second-generation antihistamines.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride
- InChIKey
- PGLIUCLTXOYQMV-GHVWMZMZSA-N
- SMILES
- C1CN(CCN1CCOCC(=O)O)[C@H](C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
- PubChem CID
- 9955977
Also known as
Levocetirizine dihydrochloride · Xyzal · Xyzal Allergy 24hr · Childrens Xyzal Allergy · good sense levocetirizine · cetirizine (R)-form dihydrochloride · CETIRIZINE HYDROCHLORIDE (R)- · Xyzall
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