API reference
Levosimendan
- CAS number
- 141505-33-1
- Molecular formula
- C14H12N6O
- Molecular weight
- 280.28 g/mol
About this molecule
Levosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. It also relaxes vascular smooth muscle by opening adenosine triphosphate sensitive potassium channels. Levosimendan is used to manage acutely decompensated congestive heart failure. Levosimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- 2-[[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile
- InChIKey
- WHXMKTBCFHIYNQ-SECBINFHSA-N
- SMILES
- C[C@@H]1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N
- PubChem CID
- 3033825
Also known as
Simdax · (R)-Simendan · levosimendanum · Simendan, (r)- · C01CX08 · 663-528-6 · Levosimedan · Simdax (TN)
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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