API reference
LOPERAMIDE HCl
- CAS number
- 34552-83-5
- Molecular formula
- C29H34Cl2N2O2
- Molecular weight
- 513.5 g/mol
About this molecule
Loperamide Hydrochloride is the hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide;hydrochloride
- InChIKey
- PGYPOBZJRVSMDS-UHFFFAOYSA-N
- SMILES
- CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl
- PubChem CID
- 71420
Also known as
Loperamide hydrochloride · Loperamide HCl · Imodium A-D · Arret · Imodium A-D EZ chews · Up and up anti diarrheal · IMODIUM ADVANCED · Diaquitte
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