API reference
Losartan potassium
- CAS number
- 124750-99-8
- Molecular formula
- C22H22ClKN6O
- Molecular weight
- 461 g/mol
About this molecule
Losartan Potassium is the potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- potassium [2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
- InChIKey
- OXCMYAYHXIHQOA-UHFFFAOYSA-N
- SMILES
- CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]
- PubChem CID
- 11751549
Also known as
LOSARTAN POTASSIUM · Cozaar · Losacar · Losaprex · Losata · Tancin · Nu-Lotan · Aradois
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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