API reference
Mefloquine
- CAS number
- 53230-10-7
- Molecular formula
- C17H16F6N2O
- Molecular weight
- 378.31 g/mol
About this molecule
Mefloquine is a quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol
- InChIKey
- XEEQGYMUWCZPDN-UHFFFAOYSA-N
- SMILES
- C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O
- Other CAS numbers recorded
- 49752-90-1
- PubChem CID
- 4046
Also known as
mefloquine · Mefloquina · Racemic mefloquine · Mefloquinum · WR 142,490 · Mephloquine · P01BC02 · WR142,490
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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