API reference
Methyldopa
- CAS number
- 555-30-6
- Molecular formula
- C10H13NO4
- Molecular weight
- 211.21 g/mol
About this molecule
Methyldopa is a phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
- InChIKey
- CJCSPKMFHVPWAR-JTQLQIEISA-N
- SMILES
- C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N
- Other CAS numbers recorded
- 88620-56-8 · 27289-76-5
- PubChem CID
- 38853
Also known as
methyldopa · Alphamethyldopa · Dopamet · Presolisin · Medomet · Alpha medopa · l-alpha-Methyldopa · Methyldopa anhydrous
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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