API reference
Methylnaltrexone bromide
- CAS number
- 916055-92-0
- Molecular formula
- C21H26BrNO4
- Molecular weight
- 436.3 g/mol
About this molecule
Methylnaltrexone Bromide is the bromide salt form of methylnaltrexone, a methyl derivative of noroxymorphone with selective, peripherally-acting mu-opioid receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, thereby reversing the opioid-related peripheral side-effects, such as constipation, urinary retention, and pruritis, respectively. Unlike naltrexone and due to the presence of a positively charged nitrogen atom in methylnaltrexone, this agent does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7-one bromide
- InChIKey
- IFGIYSGOEZJNBE-KNLJMPJLSA-N
- SMILES
- C[N+]1(CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O)CC6CC6.[Br-]
- Other CAS numbers recorded
- 73232-52-7
- PubChem CID
- 5361917
Also known as
Methylnaltrexone bromide · Relistor · Naltrexone methobromide · N-Methylnaltrexone Bromide · MOA-728 · bromuro de metilnaltrexona · bromure de methylnaltrexone · MOA728
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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