API reference
Midostaurin
- CAS number
- 120685-11-2
- Molecular formula
- C35H30N4O4
- Molecular weight
- 570.6 g/mol
About this molecule
Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors. It was approved on April 28, 2017 and has shown to increase the overall survival rate in patients with AML as an adjunct therapy along with chemotherapeutic agents.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide
- InChIKey
- BMGQWWVMWDBQGC-IIFHNQTCSA-N
- SMILES
- C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
- PubChem CID
- 9829523
Also known as
Midostaurin · PKC412 · N-Benzoylstaurosporine · PKC 412 · PKC-412 · RYDAPT · Benzoylstaurosporine · midostaurina
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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