API reference
Milrinone
- CAS number
- 78415-72-2
- Molecular formula
- C12H9N3O
- Molecular weight
- 211.22 g/mol
About this molecule
Milrinone is a cardiovascular bipyridine agent and phosphodiesterase (PDE) III inhibitor, with positive inotropic and vasodilator activities. Upon administration, milrinone selectively inhibits PDE-mediated degradation of cyclic adenosine monophosphate (cAMP) in the heart and vascular muscles, thereby increasing cAMP and activates protein kinase A (PKA). This leads to phosphorylation of calcium ion channels and improve myocardium contractile force. Milrinone also causes vasodilation in arteriolar and venous vascular smooth muscle.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
- InChIKey
- PZRHRDRVRGEVNW-UHFFFAOYSA-N
- SMILES
- CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
- PubChem CID
- 4197
Also known as
milrinone · Milrila · Milrinona · Milrinonum · Corotrop · 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile · WIN 47,203-2 · (3,4'-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-
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