API reference
Mometasone furoate
- CAS number
- 83919-23-7
- Molecular formula
- C27H30Cl2O6
- Molecular weight
- 521.4 g/mol
About this molecule
Mometasone Furoate is the furoate ester form of mometasone, a synthetic topical glucocorticoid receptor (GR) agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Upon administration, mometasone binds to cytoplasmic GRs and subsequently activates GR-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, mometasone appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
- InChIKey
- WOFMFGQZHJDGCX-ZULDAHANSA-N
- SMILES
- C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C
- PubChem CID
- 441336
Also known as
mometasone furoate · Asmanex · Elocon · Sinuva · Asmanex HFA · Asmanex Twisthaler · Mometasone furoate anhydrous · Propel Contour
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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