API reference
Nadolol
- CAS number
- 42200-33-9
- Molecular formula
- C17H27NO4
- Molecular weight
- 309.4 g/mol
About this molecule
Nadolol is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol
- InChIKey
- VWPOSFSPZNDTMJ-UCWKZMIHSA-N
- SMILES
- CC(C)(C)NCC(COC1=CC=CC2=C1C[C@@H]([C@@H](C2)O)O)O
- Other CAS numbers recorded
- 1164498-31-0 · 1403-22-1 · 220045-89-6
- PubChem CID
- 39147
Also known as
nadolol · Corgard · Solgol · Anabet · Corzide component nadolol · Nadololum · Nadolol (USP MONOGRAPH) · nadololo
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