API reference
NAFTIFINE HCl
- CAS number
- 65473-14-5
- Molecular formula
- C21H22ClN
- Molecular weight
- 323.9 g/mol
About this molecule
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2,3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine;hydrochloride
- InChIKey
- OLUNPKFOFGZHRT-YGCVIUNWSA-N
- SMILES
- CN(C/C=C/C1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32.Cl
- PubChem CID
- 5281098
Also known as
NAFTIFINE HYDROCHLORIDE · Naftifine HCl · Naftin · Exoderil · AW 105-843 · NAFT900 · NAFT-900 · N-cinnamyl-N-methyl-1-naphthalenemethylamine hydrochloride
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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