API reference
Nifurtimox
- CAS number
- 23256-30-6
- Molecular formula
- C10H13N3O5S
- Molecular weight
- 287.29 g/mol
About this molecule
Chagas disease, caused by a parasite known as Trypanosoma cruzi (T.cruzi), is a vector-transmitted disease affecting animals and humans in the Americas. It is commonly known as American Trypanosomiasis. The CDC estimates that approximately 8 million people in Central America, South America, and Mexico are infected with T. cruzi, without symptoms. If Chagas disease is left untreated, life-threatening sequelae may result. Nifurtimox, developed by Bayer, is a nitrofuran antiprotozoal drug used in the treatment of Chagas disease. On August 6 2020, accelerated FDA approval was granted for its use in pediatric patients in response to promising results from phase III clinical trials. Continued approval will be contingent upon confirmatory data. A convenient feature of Bayer's formulation is the ability to divide the scored tablets manually without the need for pill-cutting devices.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- (E)-N-(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)-1-(5-nitrofuran-2-yl)methanimine
- InChIKey
- ARFHIAQFJWUCFH-IZZDOVSWSA-N
- SMILES
- CC1CS(=O)(=O)CCN1/N=C/C2=CC=C(O2)[N+](=O)[O-]
- Other CAS numbers recorded
- 39072-15-6 · 39072-16-7
- PubChem CID
- 6842999
Also known as
Lampit · Nifurtimoxum · P01CC01 · 245-531-0 · (+)-Nifurtimox · Nifurtimox, (+)- · NIFURTIMOX (MART.) · (+/-)-Nifurtimox
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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