API reference
Nitazoxanide
- CAS number
- 55981-09-4
- Molecular formula
- C12H9N3O5S
- Molecular weight
- 307.28 g/mol
About this molecule
Nitazoxanide is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction, which is essential to anaerobic energy metabolism. PFOR enzyme reduces nitazoxanide, thereby impairing the energy metabolism. However, interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity. Nitazoxanide is active against Giardia lamblia and Cryptosporidium parvum.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
- InChIKey
- YQNQNVDNTFHQSW-UHFFFAOYSA-N
- SMILES
- CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]
- PubChem CID
- 41684
Also known as
Alinia · Nitazoxanida · Nitazoxanidum · Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)- · 2-(Acetolyloxy)-N-(5-nitro-2-thiazolyl)benzamide · Salicylamide, N-(5-nitro-2-thiazolyl)-, acetate (ester) · 2-((5-nitro-1,3-thiazol-2-yl)carbamoyl)phenyl acetate · P01AX11
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