API reference
Olaparib
- CAS number
- 763113-22-0
- Molecular formula
- C24H23FN4O3
- Molecular weight
- 434.5 g/mol
About this molecule
Olaparib is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one
- InChIKey
- FDLYAMZZIXQODN-UHFFFAOYSA-N
- SMILES
- C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
- Other CAS numbers recorded
- 937799-91-2 · 1021843-02-6
- PubChem CID
- 23725625
Also known as
Olaparib · Lynparza · Olaparibum · KEYLYNK-010 COMPONENT OLAPARIB · L01XX46 · OLAPARIB cpd · Olaparib (DISCONTINUED) · AZD221
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
Tell us the grade, the quantity and the market.
Send the molecule or ingredient, the specification and the destination. We reply from Tehran with the questions, the documents and the next step.