API reference
Pamidronate
- CAS number
- 40391-99-9
- Molecular formula
- C3H11NO7P2
- Molecular weight
- 235.07 g/mol
About this molecule
Pamidronic Acid is an amino- bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Pamidronic acid binds to and adsorbs onto hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated bone resorption, pamidronic acid decreases bone turnover rate, stabilizes the bone matrix and reduces hypercalcemia.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
- InChIKey
- WRUUGTRCQOWXEG-UHFFFAOYSA-N
- SMILES
- C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
- Other CAS numbers recorded
- 1159812-33-5 · 106437-12-1
- PubChem CID
- 4674
Also known as
PAMIDRONIC ACID · pamidronate · Amidronate · Acide pamidronique · (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid · Acido pamidronico · Acidum pamidronicum · Ribodroat
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