API reference
Paricalcitol
- CAS number
- 131918-61-1
- Molecular formula
- C27H44O3
- Molecular weight
- 416.6 g/mol
About this molecule
Paricalcitol is a synthetic noncalcemic, nonphosphatemic vitamin D analogue. Paricalcitol binds to the vitamin D receptor and has been shown to reduce parathyroid hormone (PTH) levels. This agent also increases the expression of PTEN ('Phosphatase and Tensin homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic cells and cyclin-dependent kinase inhibitors, resulting in tumor cell apoptosis and tumor cell differentiation into normal phenotypes. (NCI04)
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- trans-(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol
- InChIKey
- BPKAHTKRCLCHEA-UBFJEZKGSA-N
- SMILES
- C[C@H](/C=C/[C@H](C)C(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C3C[C@H](C[C@@H](C3)O)O)C
- Other CAS numbers recorded
- 1884139-61-0
- PubChem CID
- 5281104
Also known as
Paricalcitol · Zemplar · 19-Nor-1alpha,25-dihydroxyvitamin D2 · 19-Nor-1,25-(OH)2D2 · paricalcitolum · H05BX02 · Paracalcin · Zemplar (TN)
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