API reference
Pemigatinib
- CAS number
- 1513857-77-6
- Molecular formula
- C24H27F2N5O4
- Molecular weight
- 487.5 g/mol
About this molecule
Pemigatinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, migration, and survival.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 11-(2,6-difluoro-3,5-dimethoxyphenyl)-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1,3,6,8-tetraen-12-one
- InChIKey
- HCDMJFOHIXMBOV-UHFFFAOYSA-N
- SMILES
- CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5
- PubChem CID
- 86705695
Also known as
Pemigatinib · Pemazyre · pemigatinibum · Pemigatinib? · Pemazyre (TN) · Pemigatinib (Standard) · Pemigatinib (JAN/USAN/INN) · 2H-Pyrrolo(3',2':5,6)pyrido(4,3-d)pyrimidin-2-one,
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