API reference
Penciclovir
- CAS number
- 39809-25-1
- Molecular formula
- C10H15N5O3
- Molecular weight
- 253.26 g/mol
About this molecule
Penciclovir is a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1H-purin-6-one
- InChIKey
- JNTOCHDNEULJHD-UHFFFAOYSA-N
- SMILES
- C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N
- PubChem CID
- 135398748
Also known as
penciclovir · Denavir · Penciclovirum · Vectavir · 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine · 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine · 9-(4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL)GUANINE · 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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