API reference
Perampanel
- CAS number
- 380917-97-5
- Molecular formula
- C23H15N3O
- Molecular weight
- 349.4 g/mol
About this molecule
Perampanel is an orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with anti-epileptic activity. Although the mechanism of action through which perampanel exerts its antiepileptic effect has not been fully elucidated, this agent antagonizes the AMPA subtype of the excitatory glutamate receptor found on postsynaptic neurons in the central nervous system (CNS). This antagonistic action prevents AMPA receptor activation by glutamate and results in the inhibition of neuronal excitation, repetitive neuronal firing, and the stabilization of hyper-excited neural membranes. Glutamate, the primary excitatory neurotransmitter in the CNS, plays an important role in various neurological disorders caused by neuronal hyperexcitation.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-(2-oxo-1-phenyl-5-pyridin-2-yl-3-pyridinyl)benzonitrile
- InChIKey
- PRMWGUBFXWROHD-UHFFFAOYSA-N
- SMILES
- C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
- Other CAS numbers recorded
- 1174302-51-2
- PubChem CID
- 9924495
Also known as
Perampanel · Fycompa · perampanelum · 2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrile · N03AX22 · Fycompa (TN) · 6ZP · Perampanel (JAN/USAN)
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
Tell us the grade, the quantity and the market.
Send the molecule or ingredient, the specification and the destination. We reply from Tehran with the questions, the documents and the next step.