API reference
Primidone
- CAS number
- 125-33-7
- Molecular formula
- C12H14N2O2
- Molecular weight
- 218.25 g/mol
About this molecule
Primidone is an analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione
- InChIKey
- DQMZLTXERSFNPB-UHFFFAOYSA-N
- SMILES
- CCC1(C(=O)NCNC1=O)C2=CC=CC=C2
- PubChem CID
- 4909
Also known as
primidone · Primaclone · Mysoline · Lepimidin · 2-Deoxyphenobarbital · Lepsiral · Liskantin · Milepsin
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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