API reference
PROGUANIL HCl
- CAS number
- 637-32-1
- Molecular formula
- C11H17Cl2N5
- Molecular weight
- 290.19 g/mol
About this molecule
Proguanil Hydrochloride is the hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine;hydrochloride
- InChIKey
- SARMGXPVOFNNNG-UHFFFAOYSA-N
- SMILES
- CC(C)N=C(N)/N=C(\N)/NC1=CC=C(C=C1)Cl.Cl
- PubChem CID
- 9570076
Also known as
Proguanil hydrochloride · Chloroguanide hydrochloride · Chlorguanide hydrochloride · Paludrine · Diguanyl · Chloroquanil · Proguanil HCl · Bigumalum
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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