API reference
Propylthiouracil
- CAS number
- 51-52-5
- Molecular formula
- C7H10N2OS
- Molecular weight
- 170.23 g/mol
About this molecule
Propylthiouracil is only found in individuals that have used or taken this drug. It is a thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones.
Source: Toxin and Toxin Target Database (T3DB), via PubChem.
Identifiers
- IUPAC name
- 6-propyl-2-sulfanylidene-1H-pyrimidin-4-one
- InChIKey
- KNAHARQHSZJURB-UHFFFAOYSA-N
- SMILES
- CCCC1=CC(=O)NC(=S)N1
- Other CAS numbers recorded
- 500-50-5
- PubChem CID
- 657298
Also known as
propylthiouracil · 6-Propyl-2-thiouracil · Propacil · Procasil · Propycil · Prothyran · Prothiurone · Thiuragyl
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
Tell us the grade, the quantity and the market.
Send the molecule or ingredient, the specification and the destination. We reply from Tehran with the questions, the documents and the next step.