API reference
Pyrimethamine
- CAS number
- 58-14-0
- Molecular formula
- C12H13ClN4
- Molecular weight
- 248.71 g/mol
About this molecule
Pyrimethamine is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
- InChIKey
- WKSAUQYGYAYLPV-UHFFFAOYSA-N
- SMILES
- CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
- PubChem CID
- 4993
Also known as
pyrimethamine · Daraprim · Chloridine · 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine · Chloridin · Diaminopyritamin · Ethylpyrimidine · Pirimecidan
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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