API reference
Riociguat
- CAS number
- 625115-55-1
- Molecular formula
- C20H19FN8O2
- Molecular weight
- 422.4 g/mol
About this molecule
Riociguat is an orally bioavailable stimulator of soluble guanylate cyclase (sGC), with vasodilating activity. Upon oral administration, riociguat directly stimulates the catalytic activity of sGC. In addition, riociguat stabilizes the binding of nitric oxide (NO) to sGC. Altogether this stimulates the NO-sGC-cyclic guanosine monophosphate (cGMP) pathway and increases the formation of the intracellular second messenger cGMP, which results in smooth muscle relaxation and vasodilation. sGC, a heme-containing cytoplasmic signaling enzyme, catalyzes the formation of cGMP from guanosine triphosphate (GTP) in response to NO binding to heme. Riociguat stimulates sGC independently of and synergistically with NO.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[5,4-b]pyridin-3-yl]pyrimidin-5-yl]-N-methylcarbamate
- InChIKey
- WXXSNCNJFUAIDG-UHFFFAOYSA-N
- SMILES
- CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC
- Other CAS numbers recorded
- 1304478-72-5
- PubChem CID
- 11304743
Also known as
Riociguat · Adempas · riociguatum · C02KX05 · Riocguat-d3 · Riociguate · Riociguat CRS · GZO
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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