API reference
Ruxolitinib phosphate
- CAS number
- 1092939-17-7
- Molecular formula
- C17H21N6O4P
- Molecular weight
- 404.4 g/mol
About this molecule
Ruxolitinib Phosphate is the phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile;phosphoric acid
- InChIKey
- JFMWPOCYMYGEDM-XFULWGLBSA-N
- SMILES
- C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O
- PubChem CID
- 25127112
Also known as
Ruxolitinib phosphate · Jakafi · ruxolitinib monophosphate · ruxolitinib (as phosphate) · Jakavi · Ruxolitinib (phosphate) · OPZELURA · Ruxolitinib phosphate salt
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