API reference
Silver sulfadiazine
- CAS number
- 22199-08-2
- Molecular formula
- C10H9AgN4O2S
- Molecular weight
- 357.14 g/mol
About this molecule
Silver Sulfadiazine is a sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- silver (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
- InChIKey
- UEJSSZHHYBHCEL-UHFFFAOYSA-N
- SMILES
- C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]
- PubChem CID
- 441244
Also known as
silver sulfadiazine · SULFADIAZINE SILVER · Sulfadiazine silver salt · Flamazine · Silver sulphadiazine · Dermazin · Silvadene · Thermazene
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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