API reference
Sofosbuvir
- CAS number
- 1190307-88-0
- Molecular formula
- C22H29FN3O9P
- Molecular weight
- 529.5 g/mol
About this molecule
Sofosbuvir is an oral nucleoside analogue and potent inhibitor of the hepatitis C virus (HCV) RNA polymerase that is used in combination with other antiviral agents to treat chronic hepatitis C. Elevations in serum enzyme levels during sofosbuvir therapy are uncommon, and it has not been implicated convincingly in cases of clinically apparent liver injury with jaundice. Nevertheless, and for unknown reasons, successful antiviral therapy of hepatitis C with sofosbuvir and other direct acting agents in patients with cirrhosis is occasionally complicated by hepatic decompensation; furthermore, treatment can cause reactivation of hepatitis B in susceptible patients coinfected with the hepatitis B virus (HBV).
Source: LiverTox, via PubChem.
Identifiers
- IUPAC name
- propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
- InChIKey
- TTZHDVOVKQGIBA-IQWMDFIBSA-N
- SMILES
- C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
- PubChem CID
- 45375808
Also known as
SOVALDI · sofosbuvirum · Sovaldi Access · VOSEVI COMPONENT SOFOSBUVIR · EPCLUSA COMPONENT SOFOSBUVIR · HARVONI COMPONENT SOFOSBUVIR · J05AP08 · Hepcinat
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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