API reference
Sorafenib hemitosylate
- CAS number
- 475207-59-1
- Molecular formula
- C28H24ClF3N4O6S
- Molecular weight
- 637 g/mol
About this molecule
Sorafenib (rINN), marketed as Nexavar by Bayer, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). It has also received 'Fast Track' designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer), and has since performed well in Phase III trials. Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 & 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.
Source: Toxin and Toxin Target Database (T3DB), via PubChem.
Identifiers
- IUPAC name
- 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid
- InChIKey
- IVDHYUQIDRJSTI-UHFFFAOYSA-N
- SMILES
- CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
- Other CAS numbers recorded
- 2056030-06-7
- PubChem CID
- 406563
Also known as
Sorafenib tosylate · Nexavar · Sorafenib tosilate · 641-758-8 · Sorafenib (Tosylate) · Sorafenib Hemitosylate · Sorafenib tosilate (JAN) · Sorafenib tosylate (USAN)
Related entries in the range
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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