API reference
Stiripentol
- CAS number
- 49763-96-4
- Molecular formula
- C14H18O3
- Molecular weight
- 234.29 g/mol
About this molecule
Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs. The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzymes. However, its clinical efficacy as adjunctive therapy for epilepsies stems from its inhibitory action on CYP enzymes, as stiripentol reduces the degradation of CYP-sensitive antiepileptic drugs, hence boosting their therapeutic efficacy. Stiripentol may also exhibit direct anticonvulsant properties, although the exact mechanism of action is fully understood. Approved in the US, Canada, and Europe, stiripentol is used to treat seizures associated with Dravet syndrome. It is marketed under the brand name Diacomit.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- (E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol
- InChIKey
- IBLNKMRFIPWSOY-FNORWQNLSA-N
- SMILES
- CC(C)(C)C(/C=C/C1=CC2=C(C=C1)OCO2)O
- Other CAS numbers recorded
- 137767-55-6 · 1185239-64-8 · 131206-47-8
- PubChem CID
- 5311454
Also known as
Diacomit · Estiripentol · 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol · Stiripentolum · 4,4-Dimethyl-1-((3,4-methylenedioxy)phenyl)-1-penten-3-ol · (1E)-1-(2H-1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol · N03AX17 · 256-480-9
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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