API reference
Sulfadoxine
- CAS number
- 2447-57-6
- Molecular formula
- C12H14N4O4S
- Molecular weight
- 310.33 g/mol
About this molecule
Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties. Sulfadoxine competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of parasitic folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
- InChIKey
- PJSFRIWCGOHTNF-UHFFFAOYSA-N
- SMILES
- COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N
- Other CAS numbers recorded
- 1173021-35-6
- PubChem CID
- 17134
Also known as
Sulphadoxine · Sulfadoxin · Sulforthomidine · 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide · Sulphormethoxine · Sulfadoxina · Sulfadoxinum · Fanzil
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