API reference
Sunitinib malate
- CAS number
- 341031-54-7
- Molecular formula
- C26H33FN4O7
- Molecular weight
- 532.6 g/mol
About this molecule
Sunitinib Malate is the orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid
- InChIKey
- LBWFXVZLPYTWQI-IPOVEDGCSA-N
- SMILES
- CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O
- PubChem CID
- 6456015
Also known as
Sunitinib malate · sunitinib L-malate · Sutent · Sunitinib (Malate) · PDGF TK antagonist · Sutent (TN) · Sutent (TN) (Pfizer) · Sunitinib Malate (Sutent)
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