API reference
Tasimelteon
- CAS number
- 609799-22-6
- Molecular formula
- C15H19NO2
- Molecular weight
- 245.32 g/mol
About this molecule
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- N-[[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide
- InChIKey
- PTOIAAWZLUQTIO-GXFFZTMASA-N
- SMILES
- CCC(=O)NC[C@@H]1C[C@H]1C2=C3CCOC3=CC=C2
- PubChem CID
- 10220503
Also known as
Tasimelteon · Hetlioz · VEC-162 · VEC 162 · HETLIOZ LQ · tasimelteonum · BMS-214,778 · N05CH03
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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