API reference
Terbutaline sulfate
- CAS number
- 23031-32-5
- Molecular formula
- C24H40N2O10S
- Molecular weight
- 548.6 g/mol
About this molecule
Terbutaline Sulfate is the sulfate salt form of terbutaline, an ethanolamine derivative with bronchodilating and tocolytic properties. Terbutaline sulfate selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic cAMP production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids the relaxation of airway muscles. Terbutaline sulfate also increases mucociliary clearance and reduces release of inflammatory cell mediators.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- bis(5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol);sulfuric acid
- InChIKey
- KFVSLSTULZVNPG-UHFFFAOYSA-N
- SMILES
- CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.OS(=O)(=O)O
- PubChem CID
- 441334
Also known as
Terbutaline sulfate · Terbutaline sulphate · Brethaire · 1-(3,5-Dihydroxyphenyl)-2-tert-butylaminoethanol sulphate · Brethancer · Bretine · Monovent sa · 245-386-3
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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