API reference
Tetrabenazine
- CAS number
- 58-46-8
- Molecular formula
- C19H27NO3
- Molecular weight
- 317.4 g/mol
About this molecule
The vesicular monoamine transporter type 2 (VMAT2) inhibitors are agents that cause a depletion of neuroactive peptides such as dopamine in nerve terminals and are used to treat chorea due to neurodegenerative diseases (such as Huntington chorea) or dyskinesias due to neuroleptic medications (tardive dyskinesia). As of 2019, three VMAT2 inhibitors have become available in the United States for management of dyskinesia syndromes, each with a somewhat different spectrum of approved indications: tetrabenazine (Xenazine and generics: 2008), deutetrabenazine (Austedo: 2017) and valbenazine (Ingressa: 2017). The VMAT2 inihibitors have not been associated with serum enzyme elevations during therapy or linked to instances of clinically apparent liver injury, but they have had limited general clinical use.
Source: LiverTox, via PubChem.
Identifiers
- IUPAC name
- 9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one
- InChIKey
- MKJIEFSOBYUXJB-UHFFFAOYSA-N
- SMILES
- CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
- Other CAS numbers recorded
- 718635-93-9 · 1381929-92-5
- PubChem CID
- 6018
Also known as
Nitoman · Xenazine · Tetrabenazina · Tetrabenazinum · Revocon · Tetmodis · Xenazine 25 · (+-)-Tetrabenazine
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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