API reference
Thalidomide
- CAS number
- 50-35-1
- Molecular formula
- C13H10N2O4
- Molecular weight
- 258.23 g/mol
About this molecule
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
- InChIKey
- UEJJHQNACJXSKW-UHFFFAOYSA-N
- SMILES
- C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
- Other CAS numbers recorded
- 1012310-87-0
- PubChem CID
- 5426
Also known as
thalidomide · Thalomid · Contergan · Pantosediv · Distaval · Softenon · Kevadon · Psychotablets
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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