API reference
Thiotepa
- CAS number
- 52-24-4
- Molecular formula
- C6H12N3PS
- Molecular weight
- 189.22 g/mol
About this molecule
Thiotepa is a polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- tris(aziridin-1-yl)-sulfanylidene-lambda5-phosphane
- InChIKey
- FOCVUCIESVLUNU-UHFFFAOYSA-N
- SMILES
- C1CN1P(=S)(N2CC2)N3CC3
- Other CAS numbers recorded
- 1631739-26-8
- PubChem CID
- 5453
Also known as
thiotepa · THIO-TEPA · Triethylenethiophosphoramide · Thiophosphamide · Thioplex · Tespamin · Tespamine · Tifosyl
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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